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KMID : 0545120150250122011
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Journal of Microbiology and Biotechnology
2015 Volume.25 No. 12 p.2011 ~ p.2015
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Melanin Biosynthesis Inhibition Effects of Ginsenoside Rb2 Isolated from Panax ginseng Berry
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Lee Dae-Young
Jeong Yong-Tae
Jeong Sang-Chul
Lee Mi-Kyoung
Lee Jae-Won
Kim Geum-Soog
Lee Seung-Eun
Ahn Young-Sup
Kang Hee-Cheol
Kim Jin-Hee
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Abstract
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Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, 1H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.
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KEYWORD
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ginsenoside Rb2, Panax ginseng, melanin biosysnthesis, melan-a cell, zebrafish
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